Relationship between phase angle measured with bioelectrical impedance analysis and nonalcoholic fatty liver disease in adults
Abstract
Purpose
The phase angle (PhA) measured by bioelectrical impedance analysis (BIA) is associated with nutritional status and cellular health, and it is a clinically important parameter used to assess the risk of various diseases. It remains unclear whether PhA is associated with nonalcoholic fatty liver. The purpose of this study is to investigate the relationship between the BIA parameter PhA and nonalcoholic fatty liver disease (NAFLD).
Design/methodology/approach
This cross-sectional study was conducted with 300 adults aged 20–64 years (NAFLD: 196, normal: 104). Some biochemical findings of the participants were collected, and whole-body and segmental PhAs were measured using Tanita (MC-780) at 50 kHz.
Findings
The PhA values of the whole body (p = 0.003), trunk (p < 0.001), right and left legs (p < 0.001 for both) were found to significantly differ according to the degrees of fatty liver. It was observed that the highest PhA values were in normal individuals. Logistic regression analysis showed that the reduction in PhAs of the whole body (p = 0.038), right (p = 0.019) and left legs (p = 0.049) and trunk (p = 0.001) after adjusting for all confounding factors increased the risk of NAFLD. Additionally, whole body PhA was significantly associated with age (year, p = 0.02), BMI (kg/m2; p < 0.001), fat mass (kg; p = 0.001), fat mass (%; p < 0.001), albumin (g/L; p < 0.001) and CRP (mg/dL; p = 0.001).
Originality/value
The results of this study showed that PhA can be used in the management of NAFLD. To identify potential mechanisms in the relationship between the angle of the liver and NAFLD, large-scale prospective studies are needed.
Keywords
Acknowledgements
The authors are grateful to all individuals who participated in this study. Thanks to ChatGPT 4.0, which was used to improve language and readability in some sentences of this study.
Funding: The author declares that no funds, grants or other support were received during the preparation of this manuscript.
Authors’ contributions: Conceptualization: Mustafa Çapraz; Methodology: Cansu Memiç İnan, Mustafa Çapraz; Formal analysis: Cansu Memiç İnan; investigation: Cansu Memiç İnan; writing – original draft: Cansu Memiç İnan; supervision: Mustafa Çapraz.
Availability of data and materials: The data sets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Declaration of conflicting interests: The authors declared no potential conflicts of interest with respect to the research, authorship and/or publication of this study.
Ethical statements approval: Informed written consent was obtained from all participants prior to data collection. Ethics Committee Permission was obtained from Amasya University for this study (No. 050.01.04–102553). All study procedures were conducted according to the guidelines of the Declaration of Helsinki.
Citation
Memiç İnan, C. and Çapraz, M. (2024), "Relationship between phase angle measured with bioelectrical impedance analysis and nonalcoholic fatty liver disease in adults", Nutrition & Food Science, Vol. ahead-of-print No. ahead-of-print. https://doi.org/10.1108/NFS-04-2024-0115
Publisher
:Emerald Publishing Limited
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