Effect of propolis on glycemic control in patients with type 2 diabetes: an updated systematic review and meta-analysis of randomized controlled trials
ISSN: 0034-6659
Article publication date: 20 May 2021
Issue publication date: 6 September 2021
Abstract
Purpose
The purpose of this systematic review and meta-analysis was to investigate the efficacy of propolis on glycemic indices in type 2 diabetic patients.
Design/methodology/approach
Web of science (ISI), Embase, Scopus and PubMed were systematically searched to find randomized controlled trials (RCTs) assessing the effects of propolis intake on glycemic controls in type 2 diabetic patients, from inception up to September 1, 2020. A random-effects model was used to pool weighted mean difference (WMD). Meta-regression was performed to detect the potential sources of inter-study heterogeneity.
Findings
Seven trials were included in the meta-analysis. Compared to controls, propolis intake significantly improved serum fasting blood sugar (FBS) (WMD = −13.62 mg/dl, 95% CI = [−23.04, −4.20], P = 0.005, I2 = 58.5%) and hemoglobin A1C (HbA1c) (WMD = −0.52%, 95% CI = [−0.86, −0.18], P = 0.002, I2 = 64.0%). In contrast, receiving propolis did not change serum insulin (WMD = −1.46 (uIU/ml), 95% CI = [−2.94, 0.02], P = 0.05, I2 = 75.0%) and homeostatic model assessment for insulin resistance (HOMA-IR) (WMD = −0.98 (%), 95% CI = [−2.00, 0.04], P = 0.06, I2 = 82.3%) compared to controls.
Originality/value
The present meta-analysis demonstrated that propolis intake significantly reduces serum FBS and HbA1c in diabetic patients but does not alter serum insulin and HOMA-IR. Further large-scale RCT’s are needed to approve these effects.
Keywords
Acknowledgements
The authors thank all the participants of this study. Zahra Mosallanezhad contributed to study design, concept, literature search, data collection, analyses and drafting the manuscript. Cain Clark, Zahra Motamed, Abdolhamid Mosallanezhad and Zahra Sohrabi contributed to drafting the manuscript. Fatemeh Bahreini, Seyedeh Fatemeh Hosseini and Aneseh Shaban-Khalaf contributed to literature search and data collection. All authors read and approved the final manuscript for publication and are responsible for all aspect of this paper.
Funding: None.
Competing interest: None declared.
Ethics approval and consent to participate: Not applicable.
Citation
Mosallanezhad, Z., Clark, C., Bahreini, F., Motamed, Z., Mosallanezhad, A., Hosseini, S.F., Shaban-Khalaf, A. and Sohrabi, Z. (2021), "Effect of propolis on glycemic control in patients with type 2 diabetes: an updated systematic review and meta-analysis of randomized controlled trials", Nutrition & Food Science, Vol. 51 No. 7, pp. 1124-1137. https://doi.org/10.1108/NFS-01-2021-0026
Publisher
:Emerald Publishing Limited
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