Effects of rTMS on working memory abilities and time-varying spectrum coherence of LFPS and spikes in rats
ISSN: 0332-1649
Article publication date: 31 May 2022
Issue publication date: 12 January 2023
Abstract
Purpose
The purpose of this study was to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) at different frequencies on working memory (WM) and neuroelectric activity in rats.
Design/methodology/approach
Three rTMS protocols involving different frequencies were applied to rats, and 16-channel local field potentials (LFPs) and spikes were recorded from the prefrontal cortex (PFC) of rats in each group during the WM task. First, the behavior of rats during the T-maze task was analyzed, and then, the firing rate of spikes and the energy of the θ-band and γ-band in LFPs when rats performed the WM tasks were calculated. Finally, the spectral coherence between LFPs and spikes was analyzed by wavelet transform.
Findings
The results showed that rats in the stimulation groups needed fewer days than those in the control group to reach the task correction standard during the WM experiment (p < 0.05). High-frequency rTMS increases the firing rate of spikes and the degree of synchronization of LFPs-spikes in the θ-band and γ-band in the WM process.
Originality/value
This study showed that high-frequency rTMS can improve the spatial learning ability of rats, which might be due to the increased neuronal excitability of the PFC and the enhancement of co-coding between different modes of neural signals. This study is helpful for understanding the neuroregulatory mechanism of rTMS and will provide a reference for the selection of a suitable frequency for TMS treatment.
Keywords
Acknowledgements
Corrigendum: It has come to the attention of the publisher that the article by Miao Miao Guo, Tian Wang, Hao Di Zhai (2022), “Effects of rTMS on working memory abilities and time-varying spectrum coherence of LFPS and spikes in rats”, published in COMPEL - The international journal for computation and mathematics in electrical and electronic engineering, Vol. 42 No. 1, pp. 56-67, https://doi.org/10.1108/COMPEL-01-2022-0065, did not report the details of the ethics approval for this research within the body of the manuscript. All experiments involving animals within this paper were conducted in adherence to the Guidelines for the Ethical Review of Laboratory Animal Welfare (GB/T358922018), and ethical approval for this study was provided by the Biomedical Ethics Committee of Hebei University of Technology, Tianjin, China (HEBUTaCUC2021022). The authors sincerely apologize for this mistake.
Citation
Guo, M.M., Wang, T. and Zhai, H.D. (2023), "Effects of rTMS on working memory abilities and time-varying spectrum coherence of LFPS and spikes in rats", COMPEL - The international journal for computation and mathematics in electrical and electronic engineering, Vol. 42 No. 1, pp. 56-67. https://doi.org/10.1108/COMPEL-01-2022-0065
Publisher
:Emerald Publishing Limited
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